Your Cart

close cart

Serenelle®

4.72 32 reviews

Most anti-stress supplements work by sedating the central nervous system, causing drowsiness and impairing mental function. Serenelle® alleviates the physical and psychological symptoms of occasional stress — while actually increasing your energy and focus.*

Regular price
$24.96
Sale price
$24.96
Regular price
$29.36
Unit price
per 
Free Shipping on All US Orders Over $85

Serenelle®

Regular price
$24.96
Sale price
$24.96
Regular price
$29.36
Unit price
per 
ONE-TIME PURCHASE
OR

Highlights

  • Clinically researched doses of all ingredients
  • Sensoril® ashwagandha extract
  • PharmaGABA® gamma aminobutyric acid
  • Works in as little as 40 minutes!
  • Vegan, gluten-free, GMO-free

Benefits

  • Balances stress hormones*
  • Produces calming brain waves*
  • Relieves occasional stress*
  • Improves mood*

Why Serenelle

When you’re feeling stressed, your body goes into fight-or-flight mode, which causes a cascade of effects. Your stress hormones like cortisol surge, your brain waves switch over to a high-alert pattern, your heart hammers, your muscles tense, your concentration falters, you’re tired during the day and unable to sleep at night, and your mood tanks, leaving you sad and irritable.

You could take a stress-relief supplement, but many of them work by sedating the central nervous system, making you feel drowsy or foggy. And if your stress is caused by increased demands on you, that’s the last thing you need. Serenelle® is a research-based stress management supplement that calms without sedating.*

  • 100%
    Dairy-Free

  • 100%
    Gluten-Free

  • 100%
    GMO-Free

  • Magnesium
    Stearate Free

  • 100%
    Vegetarian

Loved by 50,000+ Customers

See all our reviews here

Buy this!

Love it! Stock up when you can! Does the trick!

Deborah B.

Grad school daughter’s saving grace!

My daughter is in Grad school and extremely stressed out...our local Health Food store recommended Serenelle and we are eternally grateful! It has made a major difference in her life...not only is she less anxious but she actually feels more focused when she takes it! We now order directly from Quality of Life and love the quick shipping and awesome price! Thank you!

Bernadette M.

Serenelle

Great product. Finally a product that works for me.

Lilit D.

Buy this!

Love it! Stock up when you can! Does the trick!

Grad school daughter’s saving grace!

My daughter is in Grad school and extremely stressed out...our local Health Food store recommended Serenelle and we are eternally grateful! It has made a major difference in her life...not only is she less anxious but she actually feels more focused when she takes it! We now order directly from Quality of Life and love the quick shipping and awesome price! Thank you!

Serenelle

Great product. Finally a product that works for me.

Learn more about
our ingredients

Relesse™ Lemon Balm

Double-blind, placebo-controlled human research shows the herb lemon balm improves stress-induced negative mood.* It works by decreasing levels of the stress hormone cortisol and increasing levels of the calming neurotransmitter GABA.*Relesse™ is a patented extract of lemon balm guaranteed to contain consistent levels of key bioactives.

Click here to view the research abstracts. 

L-theanine

L-theanine is an amino acid found in tea leaves, particularly green tea. L-theanine has been clinically shown to increase production of lower-frequency alpha brain waves, which correspond to a state of relaxed alertness.* Several studies have found it takes effect in as little as 40 minutes.

Click here to view the research abstracts. 

GABA (gamma aminobutyric acid) (PharmaGABA™)

GABA is an inhibitory neurotransmitter, meaning it has a calming effect on the brain.* It helps increase production alpha waves in the brain while decreasing nerve-jangling beta waves.* The GABA in Serenelle® is a naturally derived form, PharmaGABA®, whose relaxing properties have been proven superior to synthetic GABA in human clinical research.*

Click here to view the research abstracts. 

100% of our ingredients are backed by human clinical studies.

Click on any of the ingredients below to view the research abstracts.

Suggested Use: 2 vegicaps daily with a meal.

Serving Size: 2 vegicaps Servings Per Container: 30
Amount Per Serving % Daily Value
Lemon balm leaf extract (Melissa officinalis)
as Relesse™ [standardized to 6% rosmarinic acid (18 mg)]
300 mg †
Sensoril® ashwagandha extract
(Withaniasomnifera) roots and leaves [minimum
8% withanolide glycoside conjugates (20 mg)
and 32% oligosaccharides (80 mg)]
250 mg †
L-theanine 200 mg †
PharmaGABA®
(100 mg gamma aminobutyric acid)
125 mg †
† Daily value not established.

Other ingredients: vegetable cellulose, maltodextrin, leucine, silica.
Sensoril® is a registered trademark of Natreon Inc. and is protected under U.S. Patent #6,713,092.
PharmaGABA® is a registered trademark of Pharma Foods International Co. Ltd.

Dosage Chart

Ingredients Daily Dose Used in Human Studies Daily Dose Used in Serenelle®
Lemon balm extract (as Relesse™) 300 mg 300 mg
L-theanine 50 - 200 mg 200 mg
PharmaGABA® 100 mg 125 mg (providing
100 mg of GABA)
Sensoril® 250 mg 250 mg

Serving size: 2 vegicaps ● Daily dose: 2 vegicaps

Directions for use

Serving Size Daily Dose When to take How to take
2 Vegicaps 2 Vegicaps 1 Vegicap in the AM, 1 in the PM With meals

You, at your best

Serenelle® alleviates the physical and mental effects of occasional stress, while increasing your energy and focus.* You won’t feel drugged. You’ll just feel like you, at your best. And even better, it takes effect quickly. You’ll be feeling calm, cool, and collected in as little as 40 minutes. Here’s how it works, in four steps:

  1. Balances stress hormones, with Sensoril® ashwaganda*
  2. Produces calming alpha brain waves, with L-theanine and PharmaGABA®*
  3. Relieves signs of occasional stress, with Sensoril® ashwagandha*
  4. Improves mood, with Relesse™ lemon balm*

Trust, Efficacy, and Our Promise

We are the only brand in the supplement industry that can guarantee that every single ingredient in every one of our products is backed by human studies and delivered in doses consistent with clinical research

No exceptions, no compromises.

Satisfaction
Guarantee

You can return items purchased directly from Quality of Life Labs for any reason within 30 days of purchase. See our Returns page for full details.

Protectively
Packaged in the USA

We package almost all of our products in glass bottles with metal lids for one simple reason: Glass and metal do the best job of protecting our supplements from light, oxygen, and moisture — all of which can degrade vitamins, minerals, botanicals, and other nutraceuticals and lessen their potency and freshness.

Dosages
Matter

When you choose Quality of Life, you can trust your supplements to work, because 100 percent of the ingredients in every product we manufacture are provided in dosages that match the clinical research.

Frequently Asked Questions

  • Can you take Serenelle while taking antidepressants?

    For Serenelle it is unlikely that there would be any problem with SSRI's (Selective serotonin reuptake inhibitors). One study shows an indirect pathway for Ashwaganda (Sensoril) increasing serotonin via a cholineacetyltransferase pathway in the hippocampus of the brain. However, we do recommend consulting with a healthcare professional if you have any concerns with other medications you are taking.

  • What is the difference between synthetic GABA and PharmaGABA?

    The differences are vast. PharmaGABA is produced naturally with proven safety and efficacy. Synthetic GABA is produced from various toxic chemicals including succinimide, piperylurethan and fuming nitric acid, N-(β-bromoethyl) phthalimide and sodiomalonic ester, and γ-chlorobutyronitrile and potassium phthalimide. These compounds are regarded as noxious substances and thus prohibited to use in foods in many countries. The PharmaGABA used in our Serenelle formula is approved for food use in many countries and is both safe and effective.

  • What is the difference between all your mood products?

    Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

    • Positelle - Supports a positive mood, calmness, and a restful sleep.*
    • Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*
    • PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*

Customer Reviews

Customer Reviews
4.7 Based on 32 Reviews
5 ★
84% 
27
4 ★
9% 
3
3 ★
0% 
0
2 ★
6% 
2
1 ★
0% 
0
Write a Review Ask a Question

Thank you for submitting a review!

Your input is very much appreciated. Share it with your friends so they can enjoy it too!

Filter Reviews:
AS
05/31/2022
Amy S.
United States

Perfect!

Helps calm me very fast. I transfer from being stressed to mellow within 10 minutes.

DB
05/31/2022
Deborah B.
United States

Buy this!

Love it! Stock up when you can! Does the trick!

A
07/30/2021
Anonymous
United States

Love the product, but…..

I love Serenelle. It does just what they say it does, but it seems every time I order it, it is out of stock.


Quality of Life's Satisfaction Guarantee

You can only return items purchased directly from Quality of Life Labs for any reason within 30 days of purchase. You will receive a full refund for unopened items in the original form of payment and merchandise credit for opened items.


Quality of Life is Featured in


  • Product Reviews
  • Site Reviews
03/25/2025
Angela
United States
This was a reorder becuase i like tbe oroduct so much.
AHCC® - Kinoko® Platinum - Duo
03/23/2025
Johanna
United States
Great product! Subscription is added savings!
CoQ10-SR®
03/22/2025
JAQUELIN
United States
This product is really good is helping me alot with my skin compleción.
Oligoderm™
03/14/2025
Stephanie C.
United States
I’ve been using the Train + Recover Bundle for a few months now, and I can definitely feel the difference. I push myself pretty hard in the gym, and usually, that means dealing with soreness and fatigue for a couple of days after. But with this combo, my recovery time has seriously improved. The...I’ve been using the Train + Recover Bundle for a few months now, and I can definitely feel the difference. I push myself pretty hard in the gym, and usually, that means dealing with soreness and fatigue for a couple of days after. But with this combo, my recovery time has seriously improved. The Oligonol helps with my circulation issues and the and Curcumin has been great for keeping inflammation down. I’m not waking up as sore, and I feel like I can train harder without paying for it the next day. What I really appreciate is that these supplements don’t just rely on hype... they’re backed by science and actually work. If you’re looking for something to support your workouts and recovery, I’d definitely recommend giving this bundle a shot!
Train & Recover Bundle
03/14/2025
Anonymous
United States
My coworker brought me a bottle and said they only buy from this company and it actually works! I have been a customer ever since. It works well for sleep!
Train & Recover Bundle
03/14/2025
Andrew S.
United States
A product that actually works for me!
Train & Recover Bundle
03/14/2025
Mike T.
United States
Excellent product. I’ve used others but this was recommended by my practitioner. Longer lasting and effective.
Train & Recover Bundle
03/14/2025
Anonymous
United States
I have had bouts of insomnia for decades. Everything I have tried previously didn't work for me. I alternate between all 3 issues, trouble falling asleep, waking several times and waking hours before I should and not being able to fall back asleep. I happened to find this formula and have had a...I have had bouts of insomnia for decades. Everything I have tried previously didn't work for me. I alternate between all 3 issues, trouble falling asleep, waking several times and waking hours before I should and not being able to fall back asleep. I happened to find this formula and have had a good couple nights of sleep. THANK YOU!
Train & Recover Bundle
03/14/2025
Alex T.
United States
Highly recommend Citrulline SR for anyone looking to boost their performance.
Train & Recover Bundle
03/14/2025
Karen L.
United States
Great! Love this product! Will definitely continue ordering it. Thanks
Train & Recover Bundle
03/03/2025
Matt
United States
Great product
AHCC® - Kinoko® Platinum
02/17/2025
gerri b.
United States
I have been taking this product for five years, I panic when I run out , this is for life it works, FACT!!!!!
Kinoko® 50+ AHCC®
01/29/2025
Angela
United States
Fast shipping. High quality product with verified AHCC. I love the glass bottle with metal lid instead of plastic.
AHCC® - Kinoko® Platinum - 6 Pack
12/23/2024
Audrey
United States
It really works!
Deodorex®
12/09/2024
William
United States
Longevity Living at its best!
AHCC® - Kinoko® Platinum
12/05/2024
Rachel
United States
It's been three months since I've been taking Oligoderm, and I can really see the difference in my skin. I haven't changed anything else in my skincare routine, but now my skin looks more radiant and youthful—I wear less makeup now and love it!
Oligoderm™
12/05/2024
Rachel
US
It's been three months since I've been taking Oligoderm, and I can really see the difference in my skin. I haven't changed anything else in my skincare routine, but now my skin looks more radiant and youthful—I wear less makeup now and love it!
Oligoderm™ Trio
12/04/2024
Ethan
United States
I tend to struggle with redness in my face because of my sensitive skin, and after taking this I've noticed that it has helped reduce that! I've also noticed that it has helped with my dry skin and made my skin smoother. I definitely recommend this product to try!
Oligoderm™
12/04/2024
Edwin
United States
Unlike other stuff I used before, this one really worked. It fixed my skin damage and kept it safe. After just a few days, my skin felt smoother, looked brighter, and I loved knowing it was protected. I totally recommended it to anyone looking for a good skincare fix!
Oligoderm™
12/04/2024
Ethan
US
I tend to struggle with redness in my face because of my sensitive skin, and after taking this I've noticed that it has helped reduce that! I've also noticed that it has helped with my dry skin and made my skin smoother. I definitely recommend this product to try!
Oligoderm™ Trio
12/04/2024
Charlie
US
Been using it for several weeks and love the results so far!
Oligoderm™ Trio
12/04/2024
Edwin
US
It fixed my skin damage and kept it safe. After just a few days, my skin felt smoother, looked brighter, and I loved knowing it was protected. I totally recommended it to anyone looking for a good skincare fix!
Oligoderm™ Trio
12/03/2024
Charlie
United States
Been using it for several weeks and love the results so far!
Oligoderm™
12/03/2024
Bre
United States
I have rough spots on my skin, and after taking this product, I am obsessed with how much my skin has been repaired. I will continue to take this product, especially during the cold months, to keep my skin glowing.
Oligoderm™
12/03/2024
Judy M.
United States
My fine lines are fading, and my skin feels so hydrated. Highly recommend!
Oligoderm™
12/03/2024
Jenna L.
United States
This has completely transformed my skin—it feels softer and looks healthier. I’m hooked!
Oligoderm™
12/03/2024
Jenna L.
US
This has completely transformed my skin—it feels softer and looks healthier. I’m hooked!
Oligoderm™ Trio
12/03/2024
Judy M.
US
My fine lines are fading, and my skin feels so hydrated. Highly recommend!
Oligoderm™ Trio
12/03/2024
Bre
US
I have rough spots on my skin, and after taking this product, I am obsessed with how much my skin has been repaired. I will continue to take this product, especially during the cold months, to keep my skin glowing.
Oligoderm™ Trio
12/02/2024
Jane L.
United States
I originally bought Oligoderm™ to improve my skin, and it’s worked well for me —my complexion is brighter, smoother, and more hydrated. But what really surprised me was how much it helped with my circulation! My hands and feet don’t feel as cold anymore, especially during winter, and I just feel...I originally bought Oligoderm™ to improve my skin, and it’s worked well for me —my complexion is brighter, smoother, and more hydrated. But what really surprised me was how much it helped with my circulation! My hands and feet don’t feel as cold anymore, especially during winter, and I just feel more energized overall. It’s such a well-rounded product, and I love knowing it’s helping me from the inside out. I’ll definitely keep this in my daily routine!
Oligoderm™
REVIEWS